Genome-wide association analysis of dairy traits in Holstein cows
Author Information
Author(s): Cole John B, Wiggans George R, Ma Li, Sonstegard Tad S, Lawlor Thomas J Jr, Crooker Brian A, Van Tassell Curtis P, Yang Jing, Wang Shengwen, Matukumalli Lakshmi K, Da Yang
Primary Institution: Animal Improvement Programs Laboratory, Agricultural Research Service, USDA, Beltsville, Maryland, USA
Hypothesis
The study aims to identify genes and chromosomal regions associated with production, health, reproduction, and body conformation traits in Holstein cows.
Conclusion
The analysis identified several genes and chromosome regions associated with important dairy traits, providing valuable information for genetic improvement in Holstein cows.
Supporting Evidence
- Genome-wide association analysis identified significant SNP effects for milk, fat, and protein yields.
- Specific genes like DGAT1 and INSR were linked to important dairy traits.
- Results support the polygenic nature of the traits studied.
Takeaway
Researchers looked at the DNA of Holstein cows to find out which genes affect their milk production and health traits, helping farmers breed better cows.
Methodology
The study used a genome-wide association analysis with a 50 k SNP panel to identify genetic markers associated with 31 traits in Holstein cows.
Limitations
The study may have limitations related to the representativeness of the sample and the complexity of genetic interactions.
Participant Demographics
Contemporary U.S. Holstein cows, including elite and average individuals.
Statistical Information
P-Value
p<10-6.4
Statistical Significance
p<10-6.4
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website