Comparative Study of Carcinoembryonic Antigen in Humans and Dogs
Author Information
Author(s): Weichselbaumer Marlene, Willmann Michael, Reifinger Martin, Singer Josef, Bajna Erika, Sobanov Yuriy, Mechtcherikova Diana, Selzer Edgar, Thalhammer Johann G., Kammerer Robert, Jensen-Jarolim Erika
Primary Institution: University of Veterinary Medicine Vienna and Medical University of Vienna, Austria
Hypothesis
The study aims to phylogenetically verify the antigenic relationship of carcinoembryonic antigen (CEA) molecules and their receptors in human and canine cancer.
Conclusion
The study highlights the limitations of comparative oncology due to the complex functional evolution of CEACAM molecules in humans versus dogs, while suggesting that CEAR may be a target for cancer therapeutics.
Supporting Evidence
- Col-1 antibody reacted with 23 out of 30 canine mammary cancer samples.
- 99% amino acid similarity of human and canine CEA receptor (CEAR) was reported.
- Col-1 treatment decreased AKT-phosphorylation in canine cancer cells.
Takeaway
This study looked at a protein related to cancer in both humans and dogs to see how similar they are, which could help in treating cancer in both species.
Methodology
The study used tissue samples from canine mammary tumors and various cell lines, employing immunohistochemistry, Western blotting, flow cytometry, and phosphorylation assays.
Limitations
The lack of a known canine CEACAM5 ortholog complicates the use of comparative oncology models.
Participant Demographics
Canine mammary tumor patients, specifically female dogs.
Digital Object Identifier (DOI)
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