Association of TyG Index and TG/HDL-C Ratio with Trajectories of Depressive Symptoms: Evidence from China Health and Retirement Longitudinal Study

2024

Link Between TyG Index, TG/HDL-C Ratio, and Depression in Older Adults

Sample size: 4215 publication 10 minutes Evidence: moderate

Author Information

Author(s): Guo Tingting, Zou Qing, Wang Qi, Zhang Yi, Zhong Xinyuan, Lin Hantong, Gong Wenxuan, Wang Yingbo, Xie Kun, Wu Kunpeng, Chen Feng, Chen Wen, Moreno Luis A., Kimura Takao

Primary Institution: Sun Yat-sen University

Hypothesis

Are the triglyceride–glucose (TyG) index and the triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio associated with the trajectories of depressive symptoms in middle-aged and older adults?

Conclusion

The TyG index may be a better predictor for trajectories of depressive symptoms than the TG/HDL-C ratio in middle-aged and older adults.

Supporting Evidence

Five distinct trajectories of depressive symptoms were identified over 7 years.
Higher TyG index at baseline was associated with lower odds of being on the decreasing trajectory of depressive symptoms.
The relationship between the TG/HDL-C ratio and depressive symptoms was not statistically significant after controlling for confounders.

Takeaway

This study looked at how certain blood sugar and fat levels relate to depression in older people. It found that higher levels of one type of fat and sugar are linked to less improvement in depression over time.

Methodology

This longitudinal study analyzed data from 4215 participants aged 45 and older, using group-based trajectory modeling and multinomial logistic regression to assess the relationship between the TyG index, TG/HDL-C ratio, and depressive symptoms over 7 years.