Fast Detection of Anti-SARS-CoV-2 IgG Using Nanoparticle-Based Test Strips
Author Information
Author(s): Wang Rui, Xue Junping, Wei Guo, Zhang Yimeng, Wang Chuanliang, Li Jinhua, Geng Xuhui, Ostovan Abbas, Chen Lingxin, Song Zhihua
Primary Institution: Yantai University
Hypothesis
Can a novel SiO2@Au@CDs nanoparticle-based lateral flow immunoassay detect SARS-CoV-2 IgG antibodies quickly and sensitively?
Conclusion
The SiO2@Au@CDs nanoparticle-based lateral flow immunoassay can detect SARS-CoV-2 IgG antibodies with high sensitivity and speed.
Supporting Evidence
- The test can provide results in less than 15 minutes.
- It has a high sensitivity of 1.2 × 10−7 mg/mL.
- The linearity range for detection is broad, from 7.4 × 10−7 to 7.4 × 10−4 mg/mL.
- The system shows good stability and low cost.
- The method combines the benefits of fluorescence and lateral flow immunoassay.
Takeaway
Scientists created a new test that can quickly find antibodies for COVID-19 in people's blood using tiny particles. This test is fast and very sensitive.
Methodology
The study developed a lateral flow immunoassay using SiO2@Au@CDs nanoparticles and a miniaturized fluorimeter to detect SARS-CoV-2 IgG antibodies.
Potential Biases
Potential biases in sample selection or testing conditions are not discussed.
Limitations
The study does not specify limitations.
Digital Object Identifier (DOI)
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