CT-guided injection of cisplatin/epinephrine gel for liver tumors
Author Information
Author(s): Vogl T J, Engelmann K, Mack M G, Straub R, Zangos S, Eichler K, Hochmuth K, Orenberg E
Primary Institution: Department of Diagnostic and Interventional Radiology, JW Goethe University of Frankfurt
Hypothesis
To analyze the interventional and clinical aspects of CT-guided direct intratumoural injection of a novel chemotherapeutic administration for malignant liver tumors.
Conclusion
Direct intratumoural injection of cisplatin/epinephrine gel is a feasible and well-tolerated method that significantly increases necrosis in malignant liver tumors.
Supporting Evidence
- The treatment resulted in a significant increase in necrosis in both colorectal liver metastases and hepatocellular carcinoma.
- Local therapy control rate was 38% for colorectal metastases and 71% for hepatocellular carcinoma.
- Patients tolerated the treatment well with minimal major toxicity.
Takeaway
Doctors injected a special gel into liver tumors to help kill the cancer cells, and it worked pretty well without making patients feel too sick.
Methodology
Patients received up to 4 weekly injections of an injectable gel containing cisplatin and epinephrine, with CT scans to measure tumor and necrosis volumes.
Potential Biases
Potential bias due to the open-label design and lack of a control group.
Limitations
The study had a small sample size and was open-label, which may affect the generalizability of the results.
Participant Demographics
Average age of participants was 67.1 years, with 13 males and 4 females.
Statistical Information
P-Value
P=0.001/0.003 for necrosis increase in HCC after 2 weeks/2 months; P=0.001/0.002 for CRLM.
Confidence Interval
95% confidence interval for HCC necrosis increase.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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