Comparing Methods for Measuring Oestrogens in Tablets
Author Information
Author(s): j. D. Russell, Jr, J. Mumley, M. Spring, A. Kutz, R. N. Johnson
Primary Institution: Analytical Research and Services, Wyeth-Ayerst Research
Hypothesis
The automated spectrophotofluorometric method is as effective as the gas chromatographic method for measuring content uniformity of conjugated oestrogens in pharmaceutical preparations.
Conclusion
The automated method is faster and equally effective for routine testing of content uniformity in oestrogen tablets.
Supporting Evidence
- The automated method reduced testing time from 16 hours to 3 hours.
- Both methods produced comparable results for content uniformity.
- The coefficient of variation for the automated method was 2.57%, indicating consistency.
Takeaway
Scientists found a quicker way to check if oestrogen tablets have the right amount of medicine, which saves a lot of time.
Methodology
The study compared a gas chromatographic method with an automated spectrophotofluorometric method for measuring oestrogens in tablets.
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