Evolution of Listeria monocytogenes
Author Information
Author(s): Marie Ragon, Thierry Wirth, Florian Hollandt, Rachel Lavenir, Marc Lecuit, Alban Le Monnier, Sylvain Brisse
Primary Institution: Institut Pasteur, Paris, France
Hypothesis
What is the evolutionary history and genetic diversity of Listeria monocytogenes strains?
Conclusion
The study provides a comprehensive phylogenetic framework for understanding the evolution and virulence of Listeria monocytogenes.
Supporting Evidence
- Homologous recombination was extremely limited, indicating long-term genetic stability.
- Fifty-eight of the 126 sequence types were grouped into seven clonal complexes.
- Serotype 4b evolved once from the ancestral serotype 1/2b.
Takeaway
Scientists studied a lot of Listeria bacteria to see how they change over time and how some become less harmful.
Methodology
The study used multilocus sequence typing (MLST) to analyze 360 Listeria monocytogenes isolates.
Potential Biases
Potential bias due to the limited geographic scope of the sample collection.
Limitations
The study primarily focused on isolates from France, which may not represent global diversity.
Participant Demographics
The isolates included clinical, environmental, and food sources.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website