Azobenzene as Multi-Targeted Scaffold in Medicinal Chemistry
Author Information
Author(s): De Filippis Barbara, Della Valle Alice, Ammazzalorso Alessandra, Maccallini Cristina, Tesse Giuseppe, Amoroso Rosa, Mollica Adriano, Giampietro Letizia
Primary Institution: Department of Pharmacy, University “G. d’Annunzio”, Chieti, Italy
Hypothesis
The review aims to highlight the importance of azobenzene as a scaffold in medicinal chemistry, focusing on its chemical modifications and structure–activity relationships.
Conclusion
Azobenzene derivatives have shown a wide range of pharmacological activities, making them promising candidates for drug development.
Supporting Evidence
- Azobenzene derivatives exhibit antimicrobial, anti-inflammatory, anti-cancer, and anti-diabetic properties.
- Chemical modifications of azobenzene can significantly influence their biological activity.
- Azobenzene serves as a versatile scaffold for developing multi-target drugs.
Takeaway
Azobenzene is like a building block for making new medicines that can help with many different health problems.
Methodology
The review summarizes various synthetic strategies and biological activities of azobenzene derivatives.
Limitations
The review does not provide new experimental data but summarizes existing literature.
Digital Object Identifier (DOI)
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