Influence of metastatic site as an additional predictor for response and outcome in advanced colorectal carcinoma
1999
How the Site of Metastasis Affects Colorectal Cancer Treatment Outcomes
Sample size: 497
publication
Evidence: moderate
Author Information
Author(s): Assersohn L, Norman A, Cunningham D, Benepal T, Ross P J, Oates J
Primary Institution: Royal Marsden Hospital
Hypothesis
Does the site of metastasis influence the response to chemotherapy and survival in patients with advanced colorectal carcinoma?
Conclusion
The site of metastasis is a significant predictor of response to chemotherapy and survival in patients with advanced colorectal carcinoma.
Supporting Evidence
- 31,230 people are diagnosed with colorectal carcinoma each year.
- Up to 60% of colorectal cancer patients will develop advanced disease.
- The presence of liver metastases is a better predictor for response than performance status.
- A raised serum carcinoembryonic antigen (CEA) decreases the probability of response.
- Initial performance status is the most important predictor for survival.
Takeaway
This study found that where cancer spreads in the body can help doctors predict how well treatment will work.
Methodology
Analysis of a database of patients treated with 5-Fluorouracil-based chemotherapy in randomized clinical trials.
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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