5-Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine (tizanidine)
2011
Crystal Structure of Tizanidine
publication
Evidence: moderate
Author Information
Author(s): John Peter, Khan Islam Ullah, Akkurt Mehmet, Ramzan Muhammad Shahid, Sharif Shahzad
Primary Institution: GC University, Lahore, Pakistan
Hypothesis
What is the crystal structure of Tizanidine?
Conclusion
The study successfully determined the crystal structure of Tizanidine, revealing two independent molecules with specific conformations and hydrogen bonding interactions.
Supporting Evidence
- The study identified two independent molecules in the crystal structure of Tizanidine.
- Both molecules exhibited similar conformations and formed hydrogen bonds.
- Centrosymmetric dimers were formed through π-stacking interactions.
Takeaway
Tizanidine is a muscle relaxant, and this study shows how its molecules are arranged in a crystal, which helps us understand how it works.
Methodology
The crystal structure was determined using single-crystal X-ray diffraction.
Digital Object Identifier (DOI)
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