Preterm birth, birth weight, and subsequent risk of female breast cancer
2003

Preterm Birth and Breast Cancer Risk

Sample size: 1483 publication Evidence: high

Author Information

Author(s): Kaijser M, Akre O, Cnattingius S, Ekbom A

Primary Institution: Karolinska Hospital

Hypothesis

Does preterm birth or low birth weight increase the risk of breast cancer in women?

Conclusion

The study found that neither preterm birth nor low birth weight are associated with an increased risk for breast cancer.

Supporting Evidence

  • Neither preterm birth nor low birth weight were associated with an increased risk for cancer overall.
  • A birth weight of more than 3000 g was associated with an increased risk of breast cancer.
  • The study is the largest cohort study on long-term cancer risk among women born preterm or with low birth weight.

Takeaway

This study looked at whether being born too early or too small makes women more likely to get breast cancer later in life, and it found that it doesn't.

Methodology

The study examined birth records and followed women born between 1925 and 1949 to assess cancer risk.

Potential Biases

There may be misclassification in gestational duration due to reliance on self-reported data.

Limitations

The study subjects were born over 50 years ago, which may not reflect current health patterns.

Participant Demographics

Women born between 1925 and 1949, with a focus on those born preterm or with low birth weight.

Digital Object Identifier (DOI)

10.1038/sj.bjc.6601357

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