Effects of Angiotensin Receptors on Physical Performance in Aged Mice
Author Information
Author(s): Abadir Michael, Bene Michael, Said Adam, Marx Ruth, Powell Laura, Walston Jeremy
Primary Institution: University of Maryland
Hypothesis
The study aimed to investigate the effects of angiotensin receptors on physical performance in older mice.
Conclusion
The loss of the AT2 receptor may lead to decreased aerobic performance in aged mice, potentially due to increased body weight.
Supporting Evidence
- AT2KO mice were significantly heavier than wild type mice.
- AT2KO mice spent less time on the treadmill compared to wild type mice.
- AT2KO mice required significantly more stimuli to stay on the treadmill.
Takeaway
Mice without the AT2 receptor were heavier and performed worse on a treadmill, suggesting that this receptor helps with physical fitness as mice age.
Methodology
Aged mice were compared based on their angiotensin receptor status and underwent treadmill tests to measure performance.
Participant Demographics
Aged (24 months old) mice, including wild type and genetically modified strains.
Statistical Information
P-Value
p=0.03
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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