Brief Outpatient Rehabilitation Program for Post–COVID-19 Condition: A Randomized Clinical Trial
2024

Outpatient Rehabilitation for Post-COVID-19 Condition

Sample size: 314 publication 10 minutes Evidence: high

Author Information

Author(s): Nerli Tom Farmen MD, Selvakumar Joel MD, Cvejic Erin PhD, Heier Ingar MD, Pedersen Maria MD PhD, Johnsen Tone Langjordet PhD, Wyller Vegard Bruun Bratholm MD PhD

Primary Institution: Akershus University Hospital

Hypothesis

Is brief outpatient rehabilitation based on a cognitive and behavioral approach more effective than care as usual for improving physical function in individuals with post–COVID-19 condition (PCC)?

Conclusion

The study found that brief outpatient rehabilitation based on a cognitive and behavioral approach is effective and safe for patients with post-COVID-19 condition.

Supporting Evidence

  • Self-reported physical function improved significantly in the intervention group after 2 to 8 outpatient encounters.
  • The effect was sustained over time with negligible adverse effects.
  • Most secondary and safety measures favored the intervention group.

Takeaway

This study shows that a short rehabilitation program can help people feel better after having COVID-19, making it easier for them to do everyday activities.

Methodology

Patients with mild to moderate PCC were randomized to either an outpatient rehabilitation program or care as usual, with follow-ups at treatment completion and 12 months later.

Potential Biases

The lack of blinding for participants and therapists may introduce bias in reporting outcomes.

Limitations

The study was conducted at a single center and lacked blinding for group allocation, which may affect the results' generalizability.

Participant Demographics

The study included 314 patients, with 72% females and a mean age of 43 years.

Statistical Information

P-Value

<0.001

Confidence Interval

95% CI, 4.3-14.2

Statistical Significance

p<0.001

Digital Object Identifier (DOI)

10.1001/jamanetworkopen.2024.50744

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