The Relationship Between Metabolites and Coronary Atherosclerosis
Author Information
Author(s): Zhang Hongwei, Zheng Xiaoyu, Yan Zian, Guo Lijun, Zheng Yuan, Zhang Dawu, Ma Xiaochang
Primary Institution: National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China
Hypothesis
To investigate the causal relationship between 233 newly reported metabolites and coronary atherosclerosis through Mendelian randomization analysis.
Conclusion
There is a close relationship between metabolites and the occurrence of coronary atherosclerosis.
Supporting Evidence
- Certain metabolites increase the susceptibility risk of coronary atherosclerosis, including total fatty acids and saturated fatty acids.
- Some metabolites reduce the occurrence of coronary atherosclerosis, such as cholesteryl esters to total lipids ratio in HDL.
Takeaway
This study found that some metabolites can increase the risk of heart disease, while others can help protect against it.
Methodology
Mendelian randomization analysis using five different methods, primarily inverse variance weighting.
Potential Biases
Pleiotropy may influence the outcome through multiple biological pathways unrelated to the metabolites studied.
Limitations
Potential unmeasured confounding factors and focus on the FinnGen database may limit generalizability.
Participant Demographics
Data from up to 136,016 participants across 33 cohorts.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI: 1.28–1.53
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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