Genome Annotation Transfer Utility (GATU): A Tool for Rapid Annotation of Viral Genomes
Author Information
Author(s): Vasily Tcherepanov, Angelika Ehlers, Chris Upton
Primary Institution: Department of Microbiology and Biochemistry, University of Victoria, Victoria, BC, Canada
Hypothesis
GATU can effectively transfer annotations from a reference genome to a closely related target genome to reduce the time spent on genome annotation.
Conclusion
GATU significantly simplifies the initial stages of genome annotation by using a closely related genome as a reference.
Supporting Evidence
- GATU automatically accepted annotations for 146 out of 148 genes from the reference genome.
- The program significantly reduces the time required for genome annotation.
- GATU can handle significant variations between genomes without requiring alignment.
Takeaway
GATU is a computer program that helps scientists quickly label parts of viral genomes by using information from similar genomes.
Methodology
GATU transfers annotations from a reference genome to a target genome, detects open reading frames, and provides tools for user evaluation.
Limitations
GATU is not a comprehensive annotation system and may miss some annotations, especially for duplicated genes.
Digital Object Identifier (DOI)
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