Crystal structure of luliconazole {LCZ; C14H9Cl2N3S2; systematic name: (E)-[(4R)-4-(2,4-dichlorophenyl)-1,3-dithiolan-2-ylidene](1H-imidazol-1-yl)acetonitrile}
2025
Crystal Structure of Luliconazole
publication
Evidence: moderate
Author Information
Author(s): Ben Anna, Chęcińska Lilianna
Primary Institution: University of Lodz
Conclusion
The crystal structure of luliconazole has been determined, revealing its unique molecular conformation and intermolecular interactions.
Supporting Evidence
- The dithiolane ring adopts an envelope conformation.
- Two intermolecular C—H⋯N hydrogen bonds are observed in the crystal.
- Hirshfeld surface analysis shows dominant contacts are H⋯N/N⋯H, H⋯Cl/Cl⋯H, H⋯H, and C⋯H/H⋯C.
Takeaway
Scientists studied a medicine called luliconazole to see how its molecules are arranged. They found that the molecules have a special shape and can connect with each other in specific ways.
Methodology
The crystal structure was analyzed using X-ray diffraction techniques.
Limitations
The study does not provide information on the biological effects of luliconazole.
Digital Object Identifier (DOI)
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