Nephrotoxicity of Carboplatin in Children
Author Information
Author(s): M W English, R Skinner, A D J Pearson, L Price, R Wyllie, A W Craft
Primary Institution: Sir James Spence Institute of Child Health, The Royal Victoria Infirmary
Hypothesis
This study investigated changes in renal function in children following treatment with carboplatin and identified risk factors for nephrotoxicity.
Conclusion
High cumulative doses of carboplatin may be associated with renal damage, and monitoring of renal function is important during treatment.
Supporting Evidence
- The mean fall in GFR was 22 ml min−1 1.73 m−2.
- The mean fall in serum magnesium was 0.17 mmol l−1.
- No patient had a clinically important reduction in GFR.
- Only one patient had symptomatic hypomagnesaemia.
- GFR and serum magnesium did not change over time after treatment.
Takeaway
This study looked at how a cancer drug called carboplatin affects kids' kidneys, finding that it can cause some kidney problems, but most kids didn't have serious issues.
Methodology
Glomerular and proximal renal tubular function were investigated before and up to 2 years after treatment.
Participant Demographics
Children receiving carboplatin treatment.
Statistical Information
P-Value
P = 0.012 for GFR, P = 0.0077 for S Mg, P = 0.031 for CD, P < 0.001 for fall in S Mg, P = 0.004 for AUC.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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