HIV Protein Gp120 and Osteoblast Proliferation
Author Information
Author(s): Cummins Nathan W., Klicpera Anna, Sainski Amy M., Bren Gary D., Khosla Sundeep, Westendorf Jennifer J., Badley Andrew D.
Primary Institution: Mayo Clinic, Rochester, Minnesota, United States of America
Hypothesis
Does Gp120 induce apoptosis in osteoblasts?
Conclusion
Gp120 does not induce apoptosis in osteoblasts but may promote their proliferation in certain conditions.
Supporting Evidence
- Gp120 treatment did not induce apoptosis in osteoblast-like cells.
- Cells expressing CXCR4 showed increased proliferation when treated with Gp120.
- Proliferation was inhibited by pretreatment with a CXCR4 inhibitor.
Takeaway
The study found that a protein from HIV called Gp120 doesn't kill bone-making cells but can help them grow in some cases.
Methodology
The study used immortalized osteoblast-like cells and primary human osteoblasts to assess the effects of Gp120 on cell viability and proliferation.
Limitations
The study primarily focused on in vitro conditions, which may not fully represent in vivo effects.
Statistical Information
P-Value
<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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