Origin of Mitochondrial Macrohaplogroup 'M' in India
Author Information
Author(s): Thangaraj Kumarasamy, Chaubey Gyaneshwer, Singh Vijay Kumar, Vanniarajan Ayyasamy, Thanseem Ismail, Reddy Alla G, Singh Lalji
Primary Institution: Centre for Cellular and Molecular Biology, Hyderabad, India
Hypothesis
The study aims to reconstruct and re-evaluate the phylogeny of Macrohaplogroup M in Indian populations.
Conclusion
The study suggests that the deep rooting lineages of macrohaplogroup 'M' originated in South Asia, particularly in India.
Supporting Evidence
- The study defined a novel haplogroup M41 and revised classifications of several others.
- It was found that the Indian mtDNA pool consists of several deep rooting lineages of macrohaplogroup 'M'.
- The study suggests that these lineages are not language specific and are spread across all language groups in India.
Takeaway
Scientists studied DNA from people in India to understand where a specific group of DNA called 'M' came from, and they found it likely started in India.
Methodology
The study reconstructed a phylogenetic tree using 11 complete mtDNA sequences and 2231 partial sequences from Indian populations.
Limitations
The study's findings may not reflect the actual population size and geographical distribution due to the nature of the sample selection.
Participant Demographics
The study included diverse populations from various linguistic groups across India.
Digital Object Identifier (DOI)
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