Antimicrobial photodynamic therapy effects mediated by methylene blue in surfactant medium as an adjuvant treatment of teeth with apical periodontitis and presence of fistula–Protocol for randomized, controlled, double-blind clinical trial
2024

Using Light to Help Treat Infected Teeth

Sample size: 140 publication Evidence: moderate

Author Information

Author(s): Wince Carolina, Kassa Claudio T., Insper Joaquin, Amzallag Daniela, Consonlandich Wilhem, Tortamano Ana Carolina A. C., Magalhães Fabiana Divino, Lestido Valentina, Pavani Christiane, Prates Renato A.

Primary Institution: Universidad Catolica del Uruguay, Montevideo, Uruguay

Hypothesis

The study aims to evaluate the efficacy of photodynamic therapy as an adjunct to conventional endodontic treatment in patients with apical periodontitis and fistulas.

Conclusion

The study aims to determine if adding aPDT significantly improves the management of apical periodontitis and overall success rates of endodontic treatment.

Supporting Evidence

  • The study will assess the resolution of fistulas and improvement in radiographic signs of apical periodontitis at 15 and 30 days post-treatment.
  • Participants will be treated by a single experienced clinician to ensure consistency in data collection and procedural execution.
  • Randomization will be conducted using an online tool to ensure unbiased assignment to treatment groups.

Takeaway

This study is looking at whether a special light treatment can help heal infected teeth better when used with regular dental treatment.

Methodology

The study will involve 140 teeth with apical periodontitis and fistulas, randomly assigned to two treatment groups: one receiving conventional treatment and the other receiving conventional treatment plus aPDT.

Potential Biases

Participants and outcome evaluators will be blinded to the assigned interventions to minimize bias.

Limitations

The study may face challenges in effectively eliminating bacteria that reside within the root canals of teeth with fistulas.

Participant Demographics

Participants will be adults aged 18 and older with apical periodontitis and fistulas.

Digital Object Identifier (DOI)

10.1371/journal.pone.0315169

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