Fibrinogen E Fragment Disrupts Tumor Blood Vessels and Slows Tumor Growth
Author Information
Author(s): Brown N J, Staton C A, Rodgers G R, Corke K P, Underwood J C E, Lewis C E
Primary Institution: University of Sheffield Medical School
Hypothesis
Does fibrinogen E fragment inhibit tumor growth by disrupting tumor blood vessels?
Conclusion
Fibrinogen E fragment significantly disrupts tumor blood vessels and slows the growth of tumors in mice.
Supporting Evidence
- Fibrinogen E fragment inhibited the proliferation of endothelial cells in vitro.
- Daily injections of fibrinogen E fragment reduced tumor growth in mice.
- Fibrinogen E fragment caused significant necrosis in tumors.
- Control tumors grew steadily while fibrinogen E fragment-treated tumors showed retarded growth.
Takeaway
A piece of a blood protein can hurt the blood supply to tumors, making them grow slower.
Methodology
The study involved in vitro assays on murine endothelial cells and in vivo injections of fibrinogen E fragment in mice with CT26 tumors.
Limitations
Further studies are needed to confirm the mechanisms and effects of higher doses or different administration routes.
Participant Demographics
Balb/C mice were used in the study.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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