T-Cell Lymphoma with Hand-Mirror Cell Morphology in Eosinophilic Peritoneal Effusion
Author Information
Author(s): Richard Siderits, Janusz Godyn, Dearon Tufankjian, Osman Ouattara
Primary Institution: Robert Wood Johnson University Hospital – Hamilton
Hypothesis
Can T-cell lymphoproliferative disorders present with hand-mirror cell morphology in effusion samples?
Conclusion
The study found that a T-cell lymphoproliferative process can present with unique hand-mirror cell morphology in an effusion sample.
Supporting Evidence
- The patient presented with vague abdominal discomfort and increasing girth.
- CT imaging showed omental caking and loculated effusions.
- Cytologic evaluation revealed a monomorphic population of hand-mirror cells.
- Flow cytometry indicated an atypical T-cell population.
- TCR gene rearrangement supported the diagnosis of T-cell lymphoma.
Takeaway
This study shows that some types of blood cancer can look different in body fluids, like when doctors find special cells that look like hand mirrors.
Methodology
The case involved a 60-year-old male with abdominal discomfort, diagnosed through imaging and cytologic evaluation of ascitic fluid.
Limitations
The findings are based on a single case study, limiting generalizability.
Participant Demographics
60-year-old Caucasian male
Digital Object Identifier (DOI)
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