Brazilian Green Propolis Inhibits Inflammatory Angiogenesis in a Murine Sponge Model
2011
Brazilian Green Propolis and Inflammation
Sample size: 8
publication
Evidence: moderate
Author Information
Author(s): Sandra Aparecida Lima de Moura, Mônica Alves Neves Diniz, Silvia Passos Andrade, Maria Leticia Costa Reis, Maria de Lourdes Noviello, Denise Carmona Cara
Primary Institution: Federal University of Minas Gerais (UFMG)
Hypothesis
Propolis might prevent inflammatory angiogenesis.
Conclusion
The study found that Brazilian green propolis reduces inflammatory angiogenesis in a murine model.
Supporting Evidence
- Propolis reduced blood vessel formation in treated mice compared to controls.
- Neutrophil accumulation was unaffected, but macrophage activity decreased with propolis treatment.
- Levels of pro-inflammatory cytokines were modulated by propolis.
Takeaway
This study shows that a substance from bees called propolis can help reduce swelling and new blood vessel growth in mice.
Methodology
The study used a murine sponge model to assess the effects of water extract of green propolis on angiogenesis and inflammation over 14 days.
Participant Demographics
Female Swiss mice, 7-8 weeks old.
Statistical Information
P-Value
<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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