Vaccination Against Tuberculosis in Wild Boar
Author Information
Author(s): Garrido Joseba M., Sevilla Iker A., Beltrán-Beck Beatriz, Minguijón Esmeralda, Ballesteros Cristina, Galindo Ruth C., Boadella Mariana, Lyashchenko Konstantin P., Romero Beatriz, Geijo Maria Victoria, Ruiz-Fons Francisco, Aranaz Alicia, Juste Ramón A., Vicente Joaquín, de la Fuente José, Gortázar Christian
Primary Institution: NEIKER-Tecnalia, Animal Health Department, Derio, Bizkaia, Spain
Hypothesis
Wild boar orally and parenterally immunized with inactivated M. bovis will produce an antibody response similar to oral live BCG vaccination and natural M. bovis infection.
Conclusion
Vaccination with heat-inactivated M. bovis or BCG protects wild boar from tuberculosis.
Supporting Evidence
- Vaccination reduced the number and severity of lesions in wild boar.
- All vaccinated wild boar became infected after challenge but showed less severe disease.
- Antibody responses were observed in vaccinated groups after challenge.
- IFN-gamma responses were highest in the parenterally vaccinated group.
- Gene expression levels of C3 and MUT were analyzed as correlates of protection.
Takeaway
Researchers gave wild boar a vaccine to see if it would protect them from tuberculosis, and it worked just as well as another vaccine called BCG.
Methodology
Twenty wild boar piglets were divided into four groups and vaccinated with different formulations of M. bovis or left unvaccinated, then challenged with a field strain of M. bovis.
Limitations
The number of wild boar tested was low, limiting the statistical significance of the results.
Participant Demographics
3-4-month-old wild boar piglets.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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