Growth Hormone Therapy and Inflammation in a Child with Medulloblastoma
Author Information
Author(s): Veronica Biassoni, Federica Pallotti, Filippo Spreafico, Ettore Seregni, Lorenza Gandola, Antonella Martinetti, Emilio Bombardieri, Maura Massimino
Primary Institution: Fondazione IRCCS Istituto Nazionale per lo Studio e la Cura dei Tumori
Hypothesis
Does growth hormone replacement therapy exacerbate inflammatory lesions in children treated for medulloblastoma?
Conclusion
The case suggests a strong association between growth hormone administration and the exacerbation of inflammatory reactions within the tumor bed.
Supporting Evidence
- Growth hormone deficiency is common after craniospinal irradiation for medulloblastoma.
- Growth hormone therapy does not increase the risk of tumor recurrence.
- Inflammatory lesions were exacerbated during growth hormone therapy and improved after its suspension.
Takeaway
A girl who had brain cancer and received growth hormone treatment developed swelling and inflammation, which got better when the treatment was stopped.
Methodology
Case report detailing the patient's treatment and MRI findings over time.
Limitations
The findings are based on a single case report, limiting generalizability.
Participant Demographics
7-year-old girl with a history of metastatic medulloblastoma.
Digital Object Identifier (DOI)
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