Estimating the Burden of Vaccine-Preventable Lower Respiratory Tract Disease in UK Primary Care
Author Information
Author(s): Duncan Polly, Mears Ruth, Begier Elizabeth, Rouhbakhsh Halvaei Sanaz, Southern Jo, Porter Siân Bodfel, Hubler Robin, Oben Glenda, Qian George, Lahuerta Maria, Davis Tim, Campling James, Dawson Shoba, Christensen Hannah, Oliver Jennifer, Morales-Aza Begonia, Pan Kaijie, Gray Sharon, Hyams Catherine, Danon Leon, Gessner Bradford D, Finn Adam, Hay Alastair D, AvonCAP GP2 research group
Primary Institution: University of Bristol
Hypothesis
What is the incidence and burden of acute lower respiratory tract disease (aLRTD) in adults presenting to primary care, and how many cases are caused by vaccine-preventable infections?
Conclusion
This study will provide an accurate assessment of the burden of aLRTD due to vaccine-preventable infections in adults presenting to primary care.
Supporting Evidence
- The study aims to estimate the incidence of aLRTD and the proportion caused by vaccine-preventable infections.
- Data will be collected from electronic GP records and through patient surveys and sample collection.
- The study will provide important evidence for policymakers regarding the benefits of vaccines.
Takeaway
This study is trying to find out how many adults get sick from certain lung infections that could be prevented by vaccines, and how bad those illnesses are.
Methodology
This is a prospective cohort study involving adults aged 18 and older presenting with acute lower respiratory tract disease in six general practices in Bristol, UK.
Potential Biases
Potential bias due to reliance on coding practices and the possibility of missing cases not recorded in electronic health records.
Limitations
The study may miss cases where symptoms are recorded only in free text without a diagnostic code, and results may not be generalizable beyond the selected practices.
Participant Demographics
Adults aged 18 and older from diverse sociodemographic backgrounds in Bristol, UK.
Digital Object Identifier (DOI)
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