Thymidine phosphorylase/platelet-derived endothelial cell growth factor is upregulated in advanced solid types of gastric cancer
1999
Thymidine Phosphorylase in Advanced Gastric Cancer
Sample size: 75
publication
Evidence: moderate
Author Information
Author(s): Yoshikawa T, Suzuki K, Kobayashi O, Sairenji M, Motohashi H, Tsuburaya A, Nakamura Y, Shimizu A, Yanoma S, Noguchi Y
Primary Institution: Kanagawa Cancer Center
Hypothesis
The study investigates the production of thymidine phosphorylase in gastric cancer quantitatively.
Conclusion
Thymidine phosphorylase is up-regulated in advanced solid types of gastric cancer.
Supporting Evidence
- The amount of dThdPase was significantly higher in the tumour tissue than in the normal tissue.
- Intratumoural dThdPase concentrations were significantly higher in certain types of gastric cancer.
- In the medullary type, dThdPase levels were positively correlated with the vertical diameter of the tumour.
- High dThdPase protein levels were observed in all seven specimens tested.
Takeaway
This study found that a protein called thymidine phosphorylase is found in higher amounts in cancerous stomach tissue compared to normal tissue.
Methodology
The study used ELISA to determine dThdPase protein concentrations in tumor tissues and normal gastric mucosa specimens.
Statistical Information
P-Value
0.019
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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