Pluronic F68 block polymer, a very potent suppressor of carcinogenesis in the colon of rats and mice
2001
Pluronic F68: A Potent Colon Cancer Suppressor
Sample size: 4
publication
Evidence: high
Author Information
Author(s): Parnaud G, Taché S, Peiffer G, Corpet D E
Primary Institution: Sécurité des Aliments, INRA, Ecole Nationale Vétérinaire de Toulouse
Hypothesis
Does Pluronic F68 block polymer effectively suppress carcinogenesis in the colon of rats and mice?
Conclusion
Pluronic F68 significantly reduces the number of aberrant crypt foci in the colon, indicating its potential as a chemopreventive agent.
Supporting Evidence
- Pluronic F68 led to a 98.6% reduction in aberrant crypt foci in a rat study.
- Three additional studies confirmed the efficacy of Pluronic F68 in both rats and mice.
- Pluronic F68 is approximately five times more effective than PEG for preventing cancer.
Takeaway
Pluronic F68 is a special type of medicine that helps stop cancer from growing in the tummies of rats and mice.
Methodology
Nine PEG-like block copolymers were tested in rodents after an azoxymethane injection.
Participant Demographics
Rats and mice were used in the studies.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website