Human transporter de-oligomerization regulates copper uptake into cells
2024
How Copper Transporter 1 Regulates Copper Uptake
publication
Author Information
Author(s): Chen Tai-Yen, Wen Meng-Hsuan, Chen Huanhuan, Yan Guangjie, Zhang Yuteng, Chen Wenkai, Dokholyan Martin, Wang Jian, Dokholyan Nikolay
Hypothesis
How does the monomerization of Copper Transporter 1 (CTR1) affect copper uptake in cells?
Conclusion
Excess copper causes CTR1 to change from a trimer to a monomer, which stops copper uptake and prevents overload.
Supporting Evidence
- Copper is essential for many cellular processes but can be toxic if not regulated properly.
- CTR1 is crucial for copper uptake and maintaining copper balance in cells.
- The study found that excess copper causes CTR1 to change from a trimer to a monomer.
Takeaway
When there's too much copper, a protein called CTR1 changes shape to stop more copper from getting into the cell, which helps keep the cell safe.
Methodology
The study used single-molecule localization microscopy and single-molecule neighbor density assays to observe CTR1 behavior.
Digital Object Identifier (DOI)
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