(S)-2-Amino-2-(2-chlorophenyl)cyclohexanone C12H14ClNO
2011
Crystal Structure of S-Norketamine
publication
Evidence: moderate
Author Information
Author(s): Biermann Manfred, Hardcastle Kenneth I., Moskalev Nikolai V., Crooks Peter A.
Primary Institution: Resodyn Corporation
Hypothesis
The study aims to confirm the chiral center of the molecule S-norketamine has an S configuration.
Conclusion
The crystal structure confirms the S configuration of S-norketamine and reveals its unique molecular conformation.
Supporting Evidence
- The study confirms the chirality of S-norketamine.
- The cyclohexanone ring adopts a chair conformation.
- An N–H···O hydrogen bond links adjacent molecules into an infinite chain.
Takeaway
This study looks at a special molecule called S-norketamine to see how it is shaped and confirms it has a specific twist that makes it work better as a medicine.
Methodology
X-ray crystallography was used to determine the structure of S-norketamine.
Limitations
Data collection was incomplete at high angles, which may affect the results.
Digital Object Identifier (DOI)
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