DNA Methylation Age and Cognitive Change in Midlife
Author Information
Author(s): Bell Sophie A., Beam Christopher R., Zandi Ebrahim, Kam Alyssa, Andrews Emily, Becker Jonathan, Finkel Deborah, Davis Deborah W., Turkheimer Eric
Primary Institution: University of Virginia
Hypothesis
Does accelerated DNA methylation age predict cognitive decline in midlife, moderated by childhood socioeconomic status?
Conclusion
Accelerated DNA methylation age predicts more negative cognitive change from childhood to midlife, especially in individuals from low socioeconomic backgrounds.
Supporting Evidence
- Accelerated second generation DNA methylation age predicted more negative cognitive change.
- Childhood socioeconomic status moderated the relationship between DNA methylation age and cognitive decline.
- Results were based on a genetically informed twin design.
Takeaway
This study found that how fast your biological age is changing can affect how your thinking skills change as you get older, especially if you didn't have a lot of money when you were a kid.
Methodology
The study used a twin design to analyze the relationship between DNA methylation age and cognitive change, controlling for genetic and environmental factors.
Potential Biases
Potential recall bias in socioeconomic status measurement.
Limitations
The sample was predominantly white and from one region, which may limit generalizability.
Participant Demographics
287 middle-aged twins, mean age 51.9 years, predominantly white.
Statistical Information
P-Value
p<0.05
Confidence Interval
95% CI: [−0.35, 0.80]
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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