Mammographic Density and Breast Cancer Risk in Asian Women
Author Information
Author(s): Wong C S, Lim G H, Gao F, Jakes R W, Offman J, Chia K S, Duffy S W
Primary Institution: National University of Singapore
Hypothesis
How does mammographic density interact with other breast cancer risk factors in an Asian population?
Conclusion
Higher percent mammographic density increases breast cancer risk and modifies the effects of body mass index and oral contraceptive use.
Supporting Evidence
- Percent breast density was a significant risk factor for breast cancer after adjusting for other factors.
- Women with 76-100% density had an odds ratio of 5.54 compared to those with 0-10% density.
- Significant interactions were found between breast density and body mass index as well as oral contraceptive use.
Takeaway
Women with denser breast tissue are more likely to get breast cancer, especially if they also have other risk factors like being overweight or using birth control pills.
Methodology
The study used a case-control design with 491 breast cancer cases and 982 controls, measuring mammographic density quantitatively and analyzing data with conditional logistic regression.
Potential Biases
There may be biases related to self-reported data on risk factors and the matching process for controls.
Limitations
The study may have limited generalizability beyond the Asian population and potential biases in self-reported risk factors.
Participant Demographics
Participants were Singaporean women aged 45–69 years, predominantly Chinese.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI 2.38–12.90
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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