Evolution of the ompF Gene in the Genus Yersinia
Author Information
Author(s): Stenkova Anna M., Isaeva Marina P., Shubin Felix N., Rasskazov Valeri A., Rakin Alexander V.
Primary Institution: Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences
Hypothesis
How has the ompF gene evolved in Yersinia species?
Conclusion
The ompF gene of Yersinia has evolved under purifying selection with evidence of recombination and positive selection in certain species.
Supporting Evidence
- The ompF gene shows a high level of nucleotide diversity among Yersinia species.
- Phylogenetic analysis revealed distinct clusters for different Yersinia species based on ompF sequences.
- Evidence of positive selection was found in surface loops of the OmpF porin.
Takeaway
Scientists studied a gene called ompF in bacteria called Yersinia to see how it changes over time. They found that this gene changes in different ways depending on the type of Yersinia.
Methodology
Phylogenetic analysis of ompF gene sequences from 73 Yersinia strains covering 14 species.
Limitations
The study may not cover all genetic diversity within Yersinia due to the limited number of strains analyzed.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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