Breast Cancer Risks in Families of Patients
Author Information
Author(s): K E Bennett, A Howell, D G R Evans, J M Birch
Primary Institution: Royal Manchester Children's Hospital
Hypothesis
What are the cancer risks for relatives of breast cancer patients over a long follow-up period?
Conclusion
The study found significant excesses of breast cancer and other cancers in relatives of breast cancer patients, particularly associated with family history and age at diagnosis.
Supporting Evidence
- Relatives of breast cancer patients have a significantly higher risk of developing breast cancer themselves.
- Younger age at diagnosis in the index case increases the risk for relatives.
- The study provides valuable data for genetic counseling and risk assessment.
Takeaway
If someone in your family has had breast cancer, you might be at a higher risk of getting it too, especially if they were diagnosed young.
Methodology
The study followed 402 breast cancer patients and their first degree relatives for over 10 years, analyzing cancer registrations and deaths.
Potential Biases
Potential biases may arise from self-reported family histories and the selection of cases.
Limitations
The study may not account for all genetic factors influencing cancer risk, and the sample is limited to a specific population.
Participant Demographics
The study included female breast cancer patients diagnosed between 1984 and 1986 and their first degree relatives.
Statistical Information
P-Value
P<0.0001 for breast cancer risk
Confidence Interval
95% CI 2.0, 2.2 for familial breast cancer risk
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website