Human Chromatin Interactions and Gene Co-Expression
Author Information
Author(s): Dong Xiao, Li Chao, Chen Yunqin, Ding Guohui, Li Yixue
Primary Institution: Key Lab of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
Hypothesis
The effects of transcriptional interactome on gene co-expression exist on a genomic level.
Conclusion
The intra-chromatin interactome may relate to gene function and associate with co-expression.
Supporting Evidence
- Hi-C interactions strongly correlate with gene co-expression.
- Function-related genes are spatially close and more likely to co-express.
- The study provides genome-wide evidence of the correlation between Hi-C interaction and co-expression.
Takeaway
This study shows that genes that are close together in the genome tend to work together and express similar traits.
Methodology
The study used Hi-C experiments to analyze chromatin interactions and gene co-expression rates among 6,084 genes.
Limitations
The study is limited by the availability of Hi-C data from only two cell lines and the low resolution of the data.
Statistical Information
P-Value
0.0606
Statistical Significance
p<0.0125
Digital Object Identifier (DOI)
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