Effects of Diabetes on Rat Lung Arteries
Author Information
Author(s): Alison M. Gurney, Frank C. Howarth
Primary Institution: University of Manchester
Hypothesis
How does streptozotocin-induced diabetes affect the pharmacological reactivity of intrapulmonary arteries in rats?
Conclusion
Small resistance pulmonary arteries are relatively resistant to diabetes, while conduit arteries show impaired responsiveness to certain vasoconstrictors.
Supporting Evidence
- Diabetes was induced in rats by the β-cell toxin, streptozotocin.
- Conduit arteries showed a significant loss of responsiveness to phenylephrine and serotonin.
- Resistance arteries did not show significant changes in response to vasoconstrictors.
Takeaway
This study looked at how diabetes affects blood vessels in the lungs of rats. It found that while some blood vessels are less responsive to signals that make them constrict, others remain unaffected.
Methodology
Diabetes was induced in rats using streptozotocin, and the reactivity of isolated intrapulmonary arteries was studied using various vasoconstrictors and vasodilators.
Limitations
The study was conducted on a specific rat model and may not fully represent human physiology.
Participant Demographics
Young male Wistar rats (200–250 g)
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website