Human Infections with Plasmodium knowlesi in the Philippines
Author Information
Author(s): Luchavez Jennifer, Espino Fe, Curameng Peter, Espina Ronald, Bell David, Chiodini Peter, Nolder Debbie, Sutherland Colin, Lee Kim-Sung, Singh Balbir
Primary Institution: Research Institute for Tropical Medicine
Hypothesis
This study investigates the presence and geographic distribution of human infections with Plasmodium knowlesi in Palawan, Philippines.
Conclusion
The study confirms that human infections with Plasmodium knowlesi occur in Palawan, extending its known geographic range.
Supporting Evidence
- Five human cases of Plasmodium knowlesi infections were confirmed by nested PCR.
- The study documents autochthonous cases of P. knowlesi in the Philippines.
- Malaria transmission occurs year-round in all municipalities of Palawan.
- The primary vector for malaria in Palawan is the Anopheles flavirostris mosquito.
- Long-tailed macaques, which can harbor P. knowlesi, were observed in the area.
Takeaway
Some people in the Philippines got sick from a type of malaria that usually affects monkeys, showing it can spread to humans.
Methodology
Nested PCR assays were used to confirm the presence of Plasmodium knowlesi in blood samples from patients.
Limitations
The study is limited by the small sample size and the reliance on microscopy for initial diagnosis.
Participant Demographics
Participants were subsistence farmers, mostly men over 40 years old, living in Palawan.
Digital Object Identifier (DOI)
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