Genetic Risk Factors for Ischemic Stroke
Author Information
Author(s): Meschia James F., Singleton Andrew, Nalls Michael A., Rich Stephen S., Sharma Pankaj, Ferrucci Luigi, Matarin Mar, Hernandez Dena G., Pearce Kerra, Brott Thomas G., Brown Robert D. Jr., Hardy John, Worrall Bradford B.
Primary Institution: Mayo Clinic
Hypothesis
What are the common genetic variants contributing to ischemic stroke risk?
Conclusion
The study found no single genetic variant significantly associated with ischemic stroke, but identified trends suggesting genetic contributions to age at onset.
Supporting Evidence
- No SNP reached genome-wide significance for ischemic stroke.
- A significant cumulative effect for age at onset of stroke was identified.
- Risk profile scores based on genomic information offered little incremental prediction.
Takeaway
Researchers looked at genes to see if they could find out why some people have strokes, but they didn't find any strong links.
Methodology
The study involved a meta-analysis of genome-wide association scans from three cohorts, including genotyping and imputation of SNPs.
Potential Biases
The study may be limited by the small effect sizes of common variants and potential ascertainment bias.
Limitations
No SNP reached genome-wide significance, indicating potential limitations in detecting common genetic variants.
Participant Demographics
The study included adult men and women over the age of 18 diagnosed with ischemic stroke.
Statistical Information
P-Value
5.5×10−12
Confidence Interval
[10.85,18.68]
Statistical Significance
p<1×10−5
Digital Object Identifier (DOI)
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