Expression of Ku70 correlates with survival in carcinoma of the cervix
2000
Ku70 Expression and Cervical Cancer Survival
Sample size: 77
publication
Evidence: moderate
Author Information
Author(s): Wilson C R, Davidson S E, Margison G P, Jackson S P, Hendry J H, West C M L
Primary Institution: CRC Experimental Radiation Oncology, Carcinogenesis Groups, Department of Clinical Oncology, Christie Hospital (NHS) Trust
Hypothesis
Does the expression of Ku70 correlate with survival in cervical carcinoma patients?
Conclusion
Patients with lower Ku70 expression in their tumors tend to have higher survival rates.
Supporting Evidence
- There was a high degree of correlation between Ku70 and Ku80 expression in 77 tumors.
- Low Ku70 expression was associated with significantly higher survival rates.
- All tumors with low Ku70 or Ku80 positive cells were radiosensitive.
Takeaway
This study found that if a tumor has less Ku70, the patient might live longer after treatment.
Methodology
Immunohistochemistry was used to analyze tumor biopsies for Ku70 and Ku80 expression.
Participant Demographics
Cervical carcinoma patients in the UK.
Statistical Information
P-Value
P = 0.046
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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