EGFR Changes in Stomach Cancer
Author Information
Author(s): Moutinho Cátia, Mateus Ana R, Milanezi Fernanda, Carneiro Fátima, Seruca Raquel, Suriano Gianpaolo
Primary Institution: Instituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP)
Hypothesis
What is the frequency and type of structural alterations of the EGFR gene in primary gastric carcinomas?
Conclusion
EGFR structural alterations are rare in gastric carcinoma, but when present, they are associated with increased tumor size.
Supporting Evidence
- Two EGFR somatic mutations were found in 77 gastric carcinomas.
- Four cases showed EGFR gene amplification.
- Gastric carcinomas with EGFR alterations had a significant increase in tumor size compared to wild-type EGFR carcinomas.
Takeaway
This study looked at stomach cancer and found that changes in a specific gene called EGFR are not common, but when they do happen, they can make the tumor grow bigger.
Methodology
Direct sequencing of the EGFR gene's kinase domain and FISH analysis were performed on gastric carcinoma samples.
Limitations
The study had a small sample size for some analyses, particularly for FISH.
Participant Demographics
Patients had no family history of gastric cancer.
Statistical Information
P-Value
0.0094
Statistical Significance
p = 0.0094
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website