Cyclic cidofovir (cHPMPC) prevents congenital cytomegalovirus infection in a guinea pig model
2006
Cyclic cidofovir prevents congenital cytomegalovirus infection in guinea pigs
Sample size: 46
publication
Evidence: high
Author Information
Author(s): Schleiss Mark R, Anderson Jodi L, McGregor Alistair
Primary Institution: University of Minnesota
Hypothesis
Can antiviral therapy using cyclic cidofovir prevent congenital cytomegalovirus infection?
Conclusion
Cyclic cidofovir improves pregnancy outcomes in guinea pigs and eliminates congenital CMV infection.
Supporting Evidence
- Cyclic cidofovir-treated dams and pups had reduced mortality following GPCMV challenge.
- The treatment group had no congenital CMV transmission compared to 26% in the control group.
- Overall mortality was reduced from 20% in the placebo group to 0% in the treatment group.
Takeaway
This study shows that a medicine called cyclic cidofovir can help pregnant guinea pigs avoid passing a virus to their babies.
Methodology
Pregnant guinea pigs were treated with cyclic cidofovir after being infected with a virus, and outcomes were monitored.
Participant Demographics
Pregnant outbred Hartley guinea pigs
Statistical Information
P-Value
0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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