Intra-arterial chemotherapy for penile and anal canal cancers
Author Information
Author(s): Roth A D, Berney C R, Rohner S, Allal A S, Morel P, Marti M-C, Aapro M S, Alberto P
Primary Institution: Geneva University Hospital
Hypothesis
Intra-arterial chemotherapy may be an effective treatment for locally advanced or recurrent carcinomas of the penis and anal canal.
Conclusion
Intra-arterial chemotherapy is effective and potentially curative for advanced or recurrent cancers of the penis and anus.
Supporting Evidence
- Fifteen patients were treated for locally advanced or recurrent disease.
- Six patients achieved a complete response and eight had a partial response.
- Four complete responders are alive and disease-free 2–15 years after treatment.
Takeaway
Doctors used a special type of chemotherapy directly in the arteries to help patients with tough cancers of the penis and anus, and it worked for many of them.
Methodology
Patients received intra-arterial chemotherapy via a femoral catheter with a specific drug combination over a 48-hour period.
Limitations
Some patients experienced severe side effects, and the study had a small sample size.
Participant Demographics
Eight patients with anal canal carcinomas and eight with penile cancers.
Digital Object Identifier (DOI)
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