Tracking the connection between evolutionary and functional shifts using the fungal lipase/feruloyl esterase A family
2006
Evolutionary and Functional Shifts in Fungal Lipase Family
Sample size: 29
publication
Evidence: high
Author Information
Author(s): Anthony Levasseur, Philippe Gouret, Laureance Lesage-Meessen, Michèle Asther, Marcel Asther, Eric Record, Pierre Pontarotti
Primary Institution: Université de Provence
Hypothesis
What role does positive selection play in functional divergence?
Conclusion
The study demonstrates a connection between evolutionary and functional shifts linked to environmental changes.
Supporting Evidence
- Functional shift was suggested following a duplication event.
- Positively selected amino acids were detected.
- Biological data from mutagenesis experiments confirmed the role of selected sites.
Takeaway
Scientists studied a family of enzymes to see how they changed over time and found that these changes were related to the environment.
Methodology
Phylogenetic analysis and branch-site model were used to detect positive selection and functional shifts.
Statistical Information
P-Value
< 10-4
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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