Carbonic anhydrase XII as a good prognosis marker in breast cancer
Author Information
Author(s): Watson P H, Chia S K, Wykoff C C, Han C, Leek R D, Sly W S, Gatter K C, Ratcliffe P, Harris A L
Primary Institution: University of Manitoba
Hypothesis
Does the expression of carbonic anhydrase XII serve as a prognostic indicator in invasive breast carcinoma?
Conclusion
CA XII is frequently expressed in invasive breast carcinoma and is associated with good prognostic factors.
Supporting Evidence
- CA XII expression was observed in 75% of cases of invasive carcinoma.
- High CA XII expression was significantly associated with lower tumour grade and positive ER status.
- CA XII positive tumours were linked to longer relapse-free and overall survival.
Takeaway
This study found that a protein called CA XII is often found in breast cancer and can help doctors understand how well a patient might do.
Methodology
The study assessed CA XII expression in 103 surgically resected invasive breast carcinomas using immunohistochemistry.
Limitations
The study's relatively small sample size limited the ability to analyze CA XII and prognosis within subsets of tumours.
Participant Demographics
Median age of participants was 59 years, with a range from 28 to 83 years.
Statistical Information
P-Value
<0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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