Further Studies on Antioxidant Potential and Protection of Pancreatic β-Cells by Embelia ribes in Experimental Diabetes
2007
Antioxidant Effects of Embelia Ribes in Diabetic Rats
Sample size: 20
publication
Evidence: moderate
Author Information
Author(s): Uma Bhandari, Neeti Jain, K. K. Pillai
Primary Institution: Hamdard University, New Delhi, India
Hypothesis
Does the ethanolic extract of Embelia ribes protect pancreatic β-cells from oxidative stress in diabetic rats?
Conclusion
Embelia ribes enhances antioxidant defense and protects β-cells against damage in diabetic rats.
Supporting Evidence
- The extract significantly decreased blood glucose and glycosylated hemoglobin levels.
- Treatment with Embelia ribes restored blood glutathione levels in diabetic rats.
- The extract improved the activity of antioxidant enzymes in pancreatic tissues.
Takeaway
This study shows that a plant called Embelia ribes can help protect the pancreas in diabetic rats by fighting off harmful substances in the body.
Methodology
The study involved treating diabetic rats with ethanolic extract of Embelia ribes for 40 days and measuring various biochemical markers.
Participant Demographics
Wistar rats of either sex, weighing 150 to 200 g.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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