Genetic Factors in Breast Cancer Risk for Women with Benign Breast Disease
Author Information
Author(s): Lisa Gallicchio, Sonja I. Berndt, Meghan A. McSorley, Craig J. Newschaffer, Lucy W. Thuita, Pedram Argani, Sandra C. Hoffman, Kathy J. Helzlsouer
Primary Institution: Johns Hopkins Bloomberg School of Public Health
Hypothesis
Are genetic polymorphisms in estrogen metabolizing enzymes and estrogen receptors associated with the risk of developing breast cancer among women with benign breast disease?
Conclusion
Specific genetic polymorphisms may influence the progression of benign breast disease to breast cancer in Caucasian women.
Supporting Evidence
- The ESR2 *5772G allele was associated with a significant decrease in breast cancer risk.
- Carriers of the CYP1B1 453Ser allele had a borderline significant increase in breast cancer risk.
- The study included a large cohort of women with benign breast disease.
Takeaway
This study looked at how certain genes might affect whether women with benign breast disease develop breast cancer. Some genes seem to lower the risk, while others might increase it.
Methodology
A cohort study analyzed genetic polymorphisms in estrogen metabolizing enzymes and receptors among women with benign breast disease.
Potential Biases
Exclusions of non-Caucasian participants may limit the generalizability of the findings.
Limitations
The study had limited power due to the small number of breast cancer cases and potential misclassification of benign breast disease.
Participant Demographics
The study included 1438 Caucasian women with a mean age of 53.5 years.
Statistical Information
P-Value
0.02
Confidence Interval
95% CI 0.15, 0.96
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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