Chromosome 9 Loss in Bladder Cancer
Author Information
Author(s): Kimura F, Florl A R, Seifert H-H, Louhelainen J, Maas S, Knowles M A, Schulz W A
Primary Institution: Urologische Klinik, Center for Biological and Medical Research, Heinrich-Heine Universität, Düsseldorf, Germany
Hypothesis
The study investigates the loss of chromosome 9 in transitional cell carcinoma of the urinary bladder and its correlation with genetic alterations.
Conclusion
The study found that 51% of advanced TCC specimens showed loss of heterozygosity on chromosome 9q, indicating a potential link to tumor suppressor genes.
Supporting Evidence
- 51% of tumors showed loss of heterozygosity on chromosome 9q.
- 22% of specimens had homozygous deletions at CDKN2A.
- LOH on 9q was not related to tumor grade or stage.
Takeaway
In bladder cancer, a lot of tumors lose part of chromosome 9, which might be important for understanding how the cancer grows.
Methodology
Multiplex analysis of microsatellite markers was used to investigate loss of heterozygosity and homozygous deletions on chromosome 9q in TCC specimens.
Statistical Information
P-Value
< 0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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