Insulin-like growth factor-I and prostate cancer: a meta-analysis
2001
Insulin-like Growth Factor-I and Prostate Cancer: A Meta-Analysis
Sample size: 14
publication
Evidence: moderate
Author Information
Author(s): Shi R, Berkel H J, Yu H
Primary Institution: Feist-Weiller Cancer Center, LSUHSC-Shreveport
Hypothesis
Are high levels of insulin-like growth factor-I associated with an increased risk of prostate cancer?
Conclusion
The study found that higher levels of insulin-like growth factor-I are associated with an increased risk of prostate cancer.
Supporting Evidence
- The combined data showed that circulating levels of IGF-I were significantly higher in prostate cancer patients.
- The odds ratio for prostate cancer was 1.47 among men with high IGF-I compared to those with low IGF-I.
- The odds ratio was 1.26 for IGFBP-3.
Takeaway
This study looked at many other studies and found that men with high insulin-like growth factor-I are more likely to have prostate cancer.
Methodology
A meta-analysis of 14 case-control studies was performed to evaluate the association between IGF-I levels and prostate cancer.
Statistical Information
Confidence Interval
95% CI 1.23–1.77
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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