Impact of Anaerobic Growth Conditions on Toxic Shock Syndrome Toxin-I Production by Staphylococcus aureus
1996
Impact of Anaerobic Growth Conditions on Toxic Shock Syndrome Toxin-I Production by Staphylococcus aureus
Sample size: 20
publication
Author Information
Author(s): Max Lungren, Pongsakdi Chaisilwattana, Floyd C. Knoop, Gilles R.G. Monif
Primary Institution: Creighton University School of Medicine
Hypothesis
The impact of anaerobic growth conditions on the Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1) production was studied.
Conclusion
TSST-1 production is diminished under continued anaerobic conditions.
Supporting Evidence
- Both TSS and non-TSS strains of S. aureus exhibited comparable growth patterns under aerobic and anaerobic conditions.
- Toxin titers peaked after 24 hours of incubation.
- Under anaerobic conditions, toxin production was reduced by 2-fold compared to aerobic conditions.
Takeaway
This study found that when certain bacteria grow without oxygen, they produce less of a harmful toxin than when they grow with oxygen.
Methodology
Ten strains of S. aureus were grown under aerobic and anaerobic conditions, and toxin production was measured using the TS-RPLA latex agglutination test.
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