tert-Butyl 2-(4-nitrophenoxy)acetate
2011
Study of tert-Butyl 2-(4-nitrophenoxy)acetate
publication
Evidence: moderate
Author Information
Author(s): Ali Qamar, Anis Itrat, Raza Shah M., Ng Seik Weng
Primary Institution: H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan
Hypothesis
The study investigates the crystal structure and potential biopotency of tert-butyl 2-(4-nitrophenoxy)acetate against urease enzymes.
Conclusion
The crystal structure of the compound shows π–π stacking and weak hydrogen bonding interactions.
Supporting Evidence
- The nitrophenoxy portion of the compound is approximately planar.
- π–π stacking is observed between nearly parallel benzene rings of adjacent molecules.
- Weak intermolecular C—H⋯O hydrogen bonding is present in the crystal structure.
Takeaway
The researchers looked at a chemical compound to see how it is structured and if it can help stop certain enzymes.
Methodology
The compound was synthesized and its crystal structure was analyzed using X-ray diffraction.
Digital Object Identifier (DOI)
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